Genomic Precision

 A SeraCare blog focused on precision medicine and advanced clinical diagnostics

Mary-Claire King at the European Society for Human Genetics 2016

Her vision of genomic medicine as a dialogue at ESHG 2016 in Barcelona, Spain

Posted by Dale Yuzuki on Jun 6, 2016 3:29:24 PM

Mary-Claire King is Professor of Genome Sciences and of Medicine (Medical Genetics) at the University of Washington (Seattle, WA), who first described a single gene on chromosome 17q21 (which she named BRCA1) being responsible for breast and ovarian cancer in many families. This work, published in Science in 1990, also revolutionized the study of many other common, single-gene diseases that are inherited in nature, and led to the discovery of BRCA2. 

 

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Topics: Cancer, Inherited Disease, Oncology

American Association for Cancer Research 2016 ctDNA highlights

Circulating tumor DNA, along with immunotherapy, are two major themes of #AACR16

Posted by Dale Yuzuki on May 2, 2016 9:00:00 AM

At the American Association for Cancer Research conference recently held in New Orleans, LA (April 16 - April 20, 2016) one theme that generated considerable interest was circulating tumor DNA detection, sometimes called liquid biopsy (although that term also encompasses circulating tumor cells). A few of the ctDNA presentations are highlighted below.

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Topics: Cancer, Circulating Tumor DNA, immunotherapy

Previewing the American Association for Cancer Research 2016 Conference #AACR16

The premier cancer research conference heads to the New Orleans Convention Center April 17 - 20, 2016

Posted by Dale Yuzuki on Apr 16, 2016 9:00:00 AM

With over “Cancer Moonshot: A Call to Action” 20,000 scientists, the American Association for Cancer Research conference describes itself as a ‘must-attend event for cancer researchers and the broader cancer community’. One sign of the prominence of this event is the fact that US Vice President Joseph Biden will be delivering a special closing address, in connection with the recent announcement of the  announced at the recent World Economic Forum.

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Topics: Cancer, Genomics, cancer research

Highlights from the 2016 Molecular Medicine Tri-Conference

Diagnosing inherited disease, processing FFPE samples, state-of-the-art oncology in North Carolina, and developments in circulating tumor DNA technology

Posted by Dale Yuzuki on Mar 22, 2016 11:05:00 AM

We are living through a time of rapid change in the clinical genetics laboratory, though at times it may appear that change doesn’t occur fast enough given the challenges within the existing healthcare system. At the recent Molecular Medicine Tri-Conference held in San Francisco March 7 through 11 2016, here are a few summary highlights of the conference.

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Topics: Cancer, Circulating Tumor DNA, Inherited Disease, Genetics, Genomics, ctDNA, Reference Material, Oncology, Rare Disease

Association for Molecular Pathology 2015 Conference Highlights

Two presentations of note from the 2015 AMP Conference, Austin Texas #AMP2015

Posted by Dale Yuzuki on Nov 13, 2015 10:46:00 AM

 

Micrograph of Lung Carcinoma Fine Needle Aspirate courtesy of Ed Uthman via Flickr

This year's Association for Molecular Pathology conference was held in Austin Texas November 4-7 2015 had the theme of 'Realizing the Dream of Precision Medicine'. Here are a few of the presentations that stood out as outstanding, and the conference program indicates where the field of molecular pathology currently places its emphasis (which is primarily oncology) and where it may be headed in the coming years (including rare genetic disorders, non-invasive prenatal testing, and even a plenary on the human microbiome).

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Topics: Cancer, Pathology, Precision Medicine, Association, Oncology, Amp, CML, Therapy, Bcr-abl

Posters from AMP 2015 Available for Download

The 2015 Association for Molecular Pathology (Austin TX) posters about Reference material stabilization technology, recombinant virus, fetal trisomy patient-like material, and somatic tumor mutation profiling.

Posted by Dale Yuzuki on Nov 9, 2015 10:48:00 AM

The Association for Molecular Pathology (AMP) was founded 'to provide structure and leadership to the emerging field of molecular diagnostics', and publishes the Journal of Molecular Diagnostics.

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Topics: Cancer, LDT, Molecular Diagnostics, Accuplex, NIPS, Nipt, Prenatal Test, Posters, Standard, Oncology, SeraSeq, Amp, Conference, Molecular Pathology, Recombinant Virus

Video: What are the sources of variability in FFPE material?

Interview with Dr. Greg Tsongalis, Professor of Pathology, Dartmouth-Hitchcock Medical Center

Posted by Dale Yuzuki on Oct 27, 2015 11:16:00 AM

In this video interview Dr. Greg Tsongalis addresses sources of pre-analytic variability when processing formalin-fixed, paraffin-embedded (FFPE) samples in a pathology laboratory setting. By 'pre-analytic', he refers to the kinds of kits used for DNA extraction, and other factors that may have a significant impact on the quality of the results. He also discusses his work on clinical assay development for somatic mutation detection using NGS technology.

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Topics: Cancer, Pre-analytical, NGS, Variation, Mutation, Ffpe

Genetic Profiling of Pediatric Oncology Patients

Recent publication highlights potential of personalized medicine for young cancer patients

Posted by Russell Garlick on Oct 21, 2015 10:38:00 AM

 

There are many challenges for pediatric patients struggling with recurrent or refractory cancer but a recent report and accompanying editorial published in the Journal of American Medical Association brings new hope for patients and their families.1 2This three year study also demonstrates how the principles of precision medicine can be successfully applied with existing DNA and RNA sequencing technologies for many patients.

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Topics: Cancer, Cancer Test, Whole Exome, NGS, RNA-seq, Oncology, Pediatric, Patient Outcome

Video Interview: Why use reference materials for precision medicine?

Are you wondering why reference materials are needed for precision medicine?

Posted by Dale Yuzuki on Sep 29, 2015 10:36:00 AM

In this video interview, SeraCare’s Chief Scientific Officer Dr. Russell Garlick shares some background about  SeraCare’s history of manufacturing controls and reference materials for infectious  disease diagnostics, and how advances in Precision Medicine reveal a need for similar materials for the fields of oncology and maternal health.

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Topics: Cancer, NGS, Precision Medicine, Maternal Test, Prenatal Test, Reference Material, Standard, Test, Oncology, Non-Invasive Prenatal Testing

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