Genomic Precision

 A SeraCare blog focused on precision medicine and advanced clinical diagnostics

Reference Materials for Your Unique Reproducibility Needs

The distinction between accuracy and precision.

Posted by Matt Ryder on Oct 12, 2016 11:06:00 AM

If you took a university introductory statistics course, you may have learned the distinction between accuracy and precision.  It may likely have been presented with an archery analogy, where ‘Accurate’ was represented by arrows loosely clustered around the target’s bull’s-eye, ‘Precise’ was shown as a tight grouping displaced from the center, and ‘Accurate and Precise’ was depicted as what every archer aims for, a tight grouping directly at the bull’s-eye.  Suddenly, words that are used interchangeably in everyday conversation took on dramatically different meanings.


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Topics: NGS, Precision Medicine, FDA, Reference Material, SeraSeq, NGS assays, Tumor Mutation Mix, Sequencing quality control, Good Manufacturing Practices, variants, allele frequencies

FDA-AACR Liquid Biopsies in Oncology Drug and Device Workshop

Important information for assay development and review by the FDA

Posted by Yves Konigshofer on Aug 8, 2016 9:09:00 AM

The presentations during the FDA-AACR Liquid Biopsies in Oncology Drug and Device Development Workshop on July 19, 2016 included several important pieces of information that will likely guide the development of assays and their review by the FDA.

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Topics: Diagnostics, LDT, Cancer Test, Circulating Tumor DNA, Clinical Testing, NGS, Precision Medicine, Mutation, ctDNA, FDA, Test Development, Reference Material, Oncology

Circulating Tumor DNA Poster at Keystone Symposium

Poster Titled “New Technical Approach to Construct ctDNA Materials for use in Characterizing, Developing and Validating Plasma Assays”, available for download

Posted by Dale Yuzuki on Feb 11, 2016 10:57:00 AM

The Keystone Symposia is an organization with 44 years of history on specialized topics across the fields of molecular and cellular biology. This week in Banff, Alberta, Canada is a Keystone Symposia conference called The Cancer Genome, along with a joint meeting on Genomics and Personalized Medicine. Their Twitter description (@KeystoneSymp) describes the Keystone organization as “A catalyst for accelerating life science discovery and connecting scientists within and across disciplines at symposia worldwide”.

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Topics: Cancer Test, Circulating Tumor DNA, Precision Medicine, Variation, Mutation, ctDNA, Test Development, Reference Material, Oncology, SeraSeq

Video Interview: Developing Aneuploidy Reference Materials

Interview with Dr. Seth Harkins, Principal R&D Scientist

Posted by Dale Yuzuki on Nov 24, 2015 10:50:00 AM

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Topics: Clinical Testing, Precision Medicine, NIPS, Nipt, Maternal Health, Test Development, Reference Material, SeraSeq, Non-Invasive Prenatal Testing

Association for Molecular Pathology 2015 Conference Highlights

Two presentations of note from the 2015 AMP Conference, Austin Texas #AMP2015

Posted by Dale Yuzuki on Nov 13, 2015 10:46:00 AM

 

Micrograph of Lung Carcinoma Fine Needle Aspirate courtesy of Ed Uthman via Flickr

This year's Association for Molecular Pathology conference was held in Austin Texas November 4-7 2015 had the theme of 'Realizing the Dream of Precision Medicine'. Here are a few of the presentations that stood out as outstanding, and the conference program indicates where the field of molecular pathology currently places its emphasis (which is primarily oncology) and where it may be headed in the coming years (including rare genetic disorders, non-invasive prenatal testing, and even a plenary on the human microbiome).

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Topics: Cancer, Pathology, Precision Medicine, Association, Oncology, Amp, CML, Therapy, Bcr-abl

What is Precision Medicine?

Posted by Dale Yuzuki on Oct 13, 2015 10:37:00 AM

In 2011, the National Academy of Science published the results of a year-long committee effort called ‘Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease’. This committee was charged to explore the feasibility and need to develop a new taxonomy of human disease based upon molecular biology, with the concept that with an explosion of molecular data about individuals with disease, there was a great untapped opportunity to use these data to improve health.

FLICKR, JOHN GOODE

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Topics: Diagnostics, Precision Medicine, Reference Material, SeraSeq

Video Interview: Why use reference materials for precision medicine?

Are you wondering why reference materials are needed for precision medicine?

Posted by Dale Yuzuki on Sep 29, 2015 10:36:00 AM

In this video interview, SeraCare’s Chief Scientific Officer Dr. Russell Garlick shares some background about  SeraCare’s history of manufacturing controls and reference materials for infectious  disease diagnostics, and how advances in Precision Medicine reveal a need for similar materials for the fields of oncology and maternal health.

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Topics: Cancer, NGS, Precision Medicine, Maternal Test, Prenatal Test, Reference Material, Standard, Test, Oncology, Non-Invasive Prenatal Testing

Introducing SeraCare’s Genomic Precision Blog

SeraCare, Precision Medicine and You

Posted by Dale Yuzuki on Sep 24, 2015 10:35:00 AM

You are a translational research scientist, clinical pathologist, or laboratory test developer, always on the lookout for new tools, best practices, the latest news, and quality information. Your daily work impacts people’s heath, which is why you entered the field in the first place, and you have seen tremendous change in the past few years with breakthrough genomic technology increasingly blurring the lines between research and ‘the clinic’.

 

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Topics: NGS, Precision Medicine, Social Media, Blog

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