Genomic Precision

 A SeraCare blog focused on precision medicine and advanced clinical diagnostics

Making the Shift from Technological Innovation to Operational Excellence: Delivering on the Promise Of Next-Generation Sequencing for Personalized Medicine

Posted by Peter Duncan on Apr 22, 2019 9:44:00 AM

As originally seen in The Journal of Precision Medicine March 2019.

Targeted therapies and now recently, immunotherapies, have demonstrated great promise towards increasing response rates, as well as duration of response for cancer patients. This is often achieved by understanding biomarkers associated with therapeutic response and then stratifying patients accordingly.
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Topics: NGS, PCR

Precision Medicine and Clinical Labs: AACR Dinner Seminar Recap

Posted by Trevor Brown on Apr 15, 2019 10:30:00 AM

One of the core aims of precision medicine is to provide a more tailored approach to disease diagnosis, therapy selection, and patient monitoring to improve the overall quality of life for patients with disease. Indeed, this aim has been at the heart of the high interest and study of the potential of liquid biopsies to improve patient care in earlier detection of cancer, treatment, and surveillance.

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Topics: Precision Medicine, cfDNA, aacr

Presenting NTRK Reference Materials for Global Assay Standardization at AACR 2019

Posted by Catherine Huang on Apr 8, 2019 3:00:00 PM

On the last morning of AACR 2019, I had the privilege of presenting a poster together with my colleague, Sebastian Bender from Bayer AG, in Berlin. Because of this, I didn’t have a chance to attend any talks, but I still wanted to finish out my blog series with highlights from each day of the conference.

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Topics: SeraSeq, fusion RNA, aacr, NTRK

AACR 2019 Day Three: Understanding T-cell Therapy for Unique Cancer Mutations

Posted by Catherine Huang on Apr 4, 2019 3:03:00 PM

My third day at the AACR Annual meeting was a day of phenomenal presentations. I am struggling to choose just one to tell you about because I attended multiple inspiring, thought-provoking, and even entertaining talks today. I decided to report on the plenary presentation by Steven A. Rosenberg entitled “T-cell therapy targeting unique cancer mutations” because I think this story has the most potential to positively impact patient outcomes.

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Topics: aacr, T-cell Therapy

AACR 2019 Day Two: Learning About the Microbiome in Immuno-Oncology

Posted by Catherine Huang on Apr 3, 2019 1:50:00 PM

At the AACR Annual Meeting, I was most excited to attend the major symposium entitled “The Microbiome as an Orchestrator of Immunity and Cancer Immunotherapy,” which featured three highly informative talks. First, Gregory Sonnenberg from Weill Cornell Medicine gave an overview of how the microbiome contributes to immune homeostasis in the intestine.

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Topics: aacr, Immuno-Oncology, Microbiome

AACR 2019 Day One Highlights: Next-Generation Car T Cells

Posted by Catherine Huang on Apr 2, 2019 12:10:00 PM

I’m excited to be at the Annual AACR meeting at the Georgia World Congress Center in Atlanta, GA. AACR is my favorite scientific meeting because each year I am inspired by the remarkable research presented and leave the conference feeling I’ve learned an incredible amount in just a few days.

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Topics: next gen sequencing, aacr

New Podcast: Target the Tumor Mutational Burden and Pursue Harmonization

A Featured Speaker Podcast by Friends of Cancer Research

Posted by Melinda Fayette on Mar 20, 2019 10:00:00 AM

Friends of Cancer Research aims to better understand the impact of assay variation on clinical outcomes, align standards, and define best practices for tumor mutational burden assessment. Harmonization of methods to quantify TMB will facilitate robust biomarker development and optimize clinical utilization and treatment decision-making. 

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Topics: TMB, Friends of Cancer Research, tumor mutational burden

Video: See How an EQA Improves Clinical Genomics Testing with Affordable Custom Reference Standards

Posted by Ram Santhanam on Mar 6, 2019 10:52:00 AM

Next-generation sequencing (NGS) has revolutionized how assay developers, laboratories, and clinicians are diagnosing, treating, and monitoring disease. As NGS panels grow to include an increasing number of important biomarkers, so too must the reference standards used for development, validation, and routine QC.

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Topics: NGS assays, NGS reference materials, VariantFlex, UK NEQAS

Ground Control to Major Tom: Use Controls and Keep Your Assay Running On

Posted by Lorn Davis on Feb 28, 2019 9:55:47 AM

Labs that demonstrate best practice clinical next-generation sequencing (NGS) quality management programs utilize positive run controls, designed for this purpose, to monitor assay analytical performance across each step of the clinical NGS workflow. Common parameters for assessing the analytical performance of a clinical NGS run include sensitivity (true positives), specificity (true negatives),

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Topics: NGS assays, qc management, iQ NGS

The Full Authority Companion Diagnostic

Posted by Yves Konigshofer on Feb 21, 2019 12:30:00 PM

It is very likely that on your last flight the turbofan engines were controlled by full authority digital engine controls – FADECs for short. FADECs have played a significant role in keeping airline ticket prices low (except during holidays) by continually adjusting engine parameters so that the engine operates with maximum fuel efficiency and within operational limits, allowing pilots to focus on other tasks.

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Topics: NGS, FDA, clinical genomics, PD-L1, biomarkers

 
 
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