--- title: "Diagnostic Precision Blog | #Quality" description: "#Quality | A SeraCare blog focused on precision medicine and advanced clinical diagnostics" --- [![SeraCare](https://blog.seracare.com/hs-fs/hubfs/0.%20Logos/SeraCare/SeraCare.png?width=400&name=SeraCare.png "SeraCare")](https://www.seracare.com) - [Home](https://blog.seracare.com/ngs) - [About](https://digital.seracare.com/about-blog) - [News and Events](http://www.seracare.com/NewsEvents/NewsCenter/tabid/354/Default.aspx) - [Contact](http://www.seracare.com/Contact/tabid/366/Default.aspx) ## [Diagnostic Precision](https://blog.seracare.com/) A SeraCare blog focused on precision medicine and advanced clinical diagnostics Choose your Article Focus | [NGS](https://blog.seracare.com/ngs) | [Molecular & Serology](https://blog.seracare.com/molecular-serology-blog) ## [Evolution of non-invasive prenatal testing (NIPT)](https://blog.seracare.com/ngs/evolution-of-non-invasive-prenatal-testing-nipt-testing) Category: [New Reference Material](https://blog.seracare.com/ngs/tag/new-reference-material), [trisomy](https://blog.seracare.com/ngs/tag/trisomy), [Reproductive Health](https://blog.seracare.com/ngs/tag/reproductive-health), [NIPT](https://blog.seracare.com/ngs/tag/nipt), [Non-invasive Prenatal Testing](https://blog.seracare.com/ngs/tag/non-invasive-prenatal-testing), [NGS](https://blog.seracare.com/ngs/tag/ngs), [#Quality](https://blog.seracare.com/ngs/tag/quality), [reference materials](https://blog.seracare.com/ngs/tag/reference-materials) Posted by [Agnes Caruso,PhD](https://blog.seracare.com/ngs/author/agnes-carusophd) on Feb 5, 2020 12:00:00 AM [![](https://blog.seracare.com/hubfs/Imported_Blog_Media/istock-48289588-medium.jpg)](https://blog.seracare.com/ngs/evolution-of-non-invasive-prenatal-testing-nipt-testing) Prenatal screening for aneuploidy has changed dramatically since the 1970s. Non-invasive methods developed in the 1980s and 1990s, combined measurements of maternal serum analytes and ultrasonography. The problem with those methods was not just a high false-negative rate of 12% to 23%, a high positive rate of 5% and a poor sensitivity, ranging from 50% to 95% 1. Uncertain results frequently led to invasive procedures such as amniocentesis or chorionic villi sampling to perform karyotyping on fetal samples. Both of those procedures carry a risk of miscarriage. [Read More](https://blog.seracare.com/ngs/evolution-of-non-invasive-prenatal-testing-nipt-testing) 0 Comments [Click here to read/write comments](https://blog.seracare.com/ngs/evolution-of-non-invasive-prenatal-testing-nipt-testing#comments-listing) ## [What is Non-Invasive Prenatal Testing (NIPT)?](https://blog.seracare.com/ngs/what-is-non-invasive-prenatal-testing-nipt) Category: [New Reference Material](https://blog.seracare.com/ngs/tag/new-reference-material), [trisomy](https://blog.seracare.com/ngs/tag/trisomy), [Reproductive Health](https://blog.seracare.com/ngs/tag/reproductive-health), [NIPT](https://blog.seracare.com/ngs/tag/nipt), [#Quality](https://blog.seracare.com/ngs/tag/quality), [reference materials](https://blog.seracare.com/ngs/tag/reference-materials) Posted by [SeraCare Team](https://blog.seracare.com/ngs/author/seracare-team) on Jan 20, 2020 12:00:00 AM [![](https://blog.seracare.com/hubfs/Imported_Blog_Media/Karyotype_cr-1.jpg)](https://blog.seracare.com/ngs/what-is-non-invasive-prenatal-testing-nipt) Fetal aneuploidy affects about 9 in 1,000 live births. The definition of aneuploidy is an abnormal number of chromosomes ; with 23 pairs of chromosomes in humans, 46 is the normal number, while aneuploidy individuals will have 45 or 47. In trisomy, there is one additional chromosome, typically chr21, 18 or 13 (it is not a coincidence that these are the smallest chromosomes in humans). Historically, the invasive methods amniocentesis and chorionic villus sampling (CVS) were used with risk to the pregnancy, with about a 1% chance of miscarriage due to the procedure. Non-invasive methods based upon ultrasound and serum biomarkers are useful screening tests, but were of limited reliability as they were indirect measures of chromosomal abnormalities1. Photograph courtesy of Flickr user Can H. 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