--- title: Two Must-See Liquid Biopsy Poster Videos From AMP 2018 description: At AMP’s Annual Meeting two poster presentations on NGS-based liquid biopsy assays stood out. Both presenters described how they work to reliably detect pathogenic variants at extremely low allele frequencies – efforts critical to the clinical adoption of NGS-based liquid biopsy assays. image: https://blog.seracare.com/hubfs/Imported_Blog_Media/Video%20Analytical%20Validation%20516x-1.jpg --- ![logo](https://seracare.com/Content/themes/Skin_Default/images/lgc_logo.png) SeraCare is part of LGC Clinical Diagnostics - [Learn More](https://www.lgcclinicaldiagnostics.com/) [![SeraCare](https://blog.seracare.com/hs-fs/hubfs/0.%20Logos/SeraCare/SeraCare.png?width=400&name=SeraCare.png "SeraCare")](https://www.seracare.com) - [Home](https://blog.seracare.com/ngs) - [About](https://digital.seracare.com/about-blog) - [News and Events](http://www.seracare.com/NewsEvents/NewsCenter/tabid/354/Default.aspx) - [Contact](http://www.seracare.com/Contact/tabid/366/Default.aspx) ## [Diagnostic Precision](https://blog.seracare.com/) A SeraCare blog focused on precision medicine and advanced clinical diagnostics Choose your Article Focus | [All](https://blog.seracare.com/molecular-serology-blog) | [NGS](https://blog.seracare.com/topic/ngs) | [Molecular & Serology](https://blog.seracare.com/molecular-serology-blog/tag/molecular-serology) # Two Must-See Liquid Biopsy Poster Videos From AMP 2018 Posted by [Sam Blier](https://blog.seracare.com/ngs/author/sam-blier) on Dec 7, 2018 12:00:00 AM   [![Video Use Molecular 516x](https://blog.seracare.com/hs-fs/hubfs/Imported_Blog_Media/Video%20Use%20Molecular%20516x.jpg?width=325&name=Video%20Use%20Molecular%20516x.jpg)](https://www.seracare.com/resources-and-education/videos/use-molecular-identifiers-targeted-ngs-enable-variant-detection-below-1-allele-frequencies-ccfdna/) Of the many fantastic posters presented at AMP’s Annual Meeting in San Antonio, two concerning NGS-based liquid biopsy assays stood out. Both presenters described how their organizations are working to reliably detect pathogenic variants at extremely low allele frequencies – efforts critical to the clinical adoption of NGS-based liquid biopsy assays. Swift Biosciences presented some very interesting data on molecular identifiers (MIDs) that enable accurate variant detection below 1% AF in ctDNA. They used the **[Seraseq ctDNA Reference Material v2](https://www.seracare.com/Seraseq-ctDNA-Reference-Material-v2-AF025-0710-0206/)** to test their assay’s limit of detection. **[Click here to download the poster and watch](https://www.seracare.com/resources-and-education/videos/use-molecular-identifiers-targeted-ngs-enable-variant-detection-below-1-allele-frequencies-ccfdna/)** Swift’s Francesco Criscuolo explain how Swift’s MID technology can improve NGS data analysis with his poster *Use of Molecular Identifiers and Targeted NGS to Enable Variant Detection Below 1% Allele Frequencies in Circulating Cell-Free DNA*. [![Video Analytical Validation 516x-1](https://blog.seracare.com/hs-fs/hubfs/Imported_Blog_Media/Video%20Analytical%20Validation%20516x-1.jpg?width=325&name=Video%20Analytical%20Validation%20516x-1.jpg)](https://www.seracare.com/resources-and-education/videos/analytical-validation-oncomine-breast-cfdna-assay-v2/) Another compelling poster was presented by MolecularMD’s Dr. WeiHua Liu. Her team took a methodical approach to validating the Oncomine Breast cfDNA Assay v2 and used both the **[Seraseq ctDNA Complete Mutation Mix](https://www.seracare.com/Seraseq-ctDNA-Complete-Mutation-Mix-AF01-0710-0532/)** and **[ctDNA Mutation Mix v2](https://www.seracare.com/Seraseq-ctDNA-Mutation-Mix-v2-AF1-0710-0140/)** reference materials to determine the amount of DNA input needed to reproducibly detect SNVs at 0.1% AF. **[Check out her poster presentation video](https://www.seracare.com/resources-and-education/videos/analytical-validation-oncomine-breast-cfdna-assay-v2/)**, titled *Analytical Validation of Oncomine Breast cfDNA Assay v2,* to learn more about their methodology. Want to learn more about our QC and validation solutions for NGS-based liquid biopsy assays? **[Click here](https://www.seracare.com/Controls---Reference-Materials-NGS-Somatic-Cancer-Liquid-Biopsy/).** --- **To watch the videos and download these free posters, click each title below:** [![Analytical Validation of Oncomine Breast cfDNA Assay v2 poster](https://blog.seracare.com/hs-fs/hubfs/Imported_Blog_Media/Analytical%20Validation%20of%20Oncomine%20Breast%20cfDNA%20Assay%20v2%20poster.png?width=250&name=Analytical%20Validation%20of%20Oncomine%20Breast%20cfDNA%20Assay%20v2%20poster.png)](https://www.seracare.com/resources-and-education/videos/analytical-validation-oncomine-breast-cfdna-assay-v2/)  **[Analytical Validation of Oncomine Breast cfDNA Assay v2](https://www.seracare.com/resources-and-education/videos/analytical-validation-oncomine-breast-cfdna-assay-v2/)** [![Use of Molecular Identifiers and Targeted NGS to Enable Variant Detection Below 1 Allele Frequencies in Circulating Cell-Free DNA poster](https://blog.seracare.com/hs-fs/hubfs/Imported_Blog_Media/Use%20of%20Molecular%20Identifiers%20and%20Targeted%20NGS%20to%20Enable%20Variant%20Detection%20Below%201%20Allele%20Frequencies%20in%20Circulating%20Cell-Free%20DNA%20poster.png?width=250&name=Use%20of%20Molecular%20Identifiers%20and%20Targeted%20NGS%20to%20Enable%20Variant%20Detection%20Below%201%20Allele%20Frequencies%20in%20Circulating%20Cell-Free%20DNA%20poster.png)](https://www.seracare.com/resources-and-education/videos/use-molecular-identifiers-targeted-ngs-enable-variant-detection-below-1-allele-frequencies-ccfdna/) **[Use of Molecular Identifiers and Targeted NGS to Enable Variant Detection Below 1% Allele Frequencies in Circulating Cell-Free DNA](https://www.seracare.com/resources-and-education/videos/use-molecular-identifiers-targeted-ngs-enable-variant-detection-below-1-allele-frequencies-ccfdna/)** Topics: [AMP](https://blog.seracare.com/ngs/tag/amp), [SeraSeq](https://blog.seracare.com/ngs/tag/seraseq), [liquid biopsy](https://blog.seracare.com/ngs/tag/liquid-biopsy), [cfDNA](https://blog.seracare.com/ngs/tag/cfdna), [ctDNA](https://blog.seracare.com/ngs/tag/ctdna)     ### Subscribe Here!   [![New call-to-action](https://no-cache.hubspot.com/cta/default/20300467/538d26d7-6bf8-4208-9dad-6a783db06a0c.png)](https://cta-redirect.hubspot.com/cta/redirect/20300467/538d26d7-6bf8-4208-9dad-6a783db06a0c) ### Posts by Tag - 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508-634-3334 Fax - - - ![logo](https://blog.seracare.com/hubfs/logo.png "logo") 37 Birch Street Milford, MA 01757 508-244-6400 508-634-3334 Fax #### Products #### SeraCare #### Support & Resources - NGS & Digital PCR Tools - Controls & Reference Materials - Validation & Qualification Materials - Plasma & Serum Diluents & Derivatives - Cell Culture Reagents - KPL Antibodies & Conjugates - KPL Immunoassay Reagents & Kits - About Us - Careers - Press Releases - News Articles - Quality Systems - Terms & Conditions - Privacy Policy & Legal Statement - Register for an Account - Contact Us - Sign In - Resource Library - FAQs - Scientific Posters - White Papers - Videos ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Sam Blier", "url" : "https://blog.seracare.com/ngs/author/sam-blier" }, "dateModified" : "2021-10-15T02:45:37.419Z", "datePublished" : "2018-12-07T05:00:00.000Z", "headline" : "Two Must-See Liquid Biopsy Poster Videos From AMP 2018", "image" : [ "https://blog.seracare.com/hubfs/Imported_Blog_Media/Video%20Analytical%20Validation%20516x-1.jpg" ], "mainEntityOfPage" : { "@id" : "https://blog.seracare.com/ngs/two-must-see-liquid-biopsy-posters-from-amp-2018", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.seracare.com/hubfs/0.%20Logos/SeraCare/SeraCare.png" }, "name" : "LGC Clinical Diagnostics" } } ```